The dermis, or innermost layer, is responsible for providing structure and support to the skin. Eczema is believed to arise when the body’s immune system is triggered into an abnormal, overactive, inflammatory response that involves both the epidermis and the dermis.
What skin structures are affected by eczema?
Children, teenagers and adults who have eczema are most commonly affected on the backs of their knees, the insides of their elbows and the back of the neck. The itchy rash may also develop on the palms of their hands and soles of their feet. It rarely affects the face.
What parts of the body are most affected by atopic dermatitis?
What parts of the body are affected? The part or parts of the body affected by atopic dermatitis tends to change as a child ages. In infants and young children, it’s usually the face, trunk and extremities. In older children and adults, atopic dermatitis tends to appear on the creases if the arms and back of the legs.
Can eczema affect your internal organs?
Atopic dermatitis also affects the immune system, he says, which puts patients at risk for internal infections, including those of the upper respiratory tract and urinary tract.
How does eczema affect the tissue?
When you have atopic dermatitis, the outer layer of skin is weaker and more susceptible to inflammation caused by immune cells in the body. The damage done by scratching also contributes to the breakdown of skin cells, making it easier for foreign substances to get in.
What is the science behind eczema?
For the past decade, scientists have known that eczema is associated with a genetic lack of filaggrin (filament aggregating protein) in the skin. This protein helps shape individual skin cells, and plays an important role in our skin’s barrier function.
What genes cause eczema?
Researchers have identified that mutations in KIF3A, FLG, and CARD11 genes are commonly associated with the development of eczema. Other factors can also cause eczema.
Is eczema an autoimmune disease?
For the first time, a team led by researchers at the Icahn School of Medicine at Mount Sinai has proven that atopic dermatitis, also known as eczema, is an immune-driven (autoimmune) disease at the molecular level.
Can eczema affect your whole body?
Eczema has been linked to an increased risk of health conditions such as asthma, hay fever, food allergy, obesity and heart disease, Silverberg said. The reasons for this are unclear. But, the connection may be eczema-related inflammation affecting the entire body, he said.
What autoimmune disease is associated with eczema?
Some primary immunodeficiency diseases are, however, associated with more severe eczema. These include WAS, Hyper-IgE Syndrome (HIES), IPEX syndrome, and certain forms of Severe Combined Immune Deficiency (SCID).
What foods trigger eczema flare ups?
Some common foods that may trigger an eczema flare-up and could be removed from a diet include:
- citrus fruits.
- gluten or wheat.
- spices, such as vanilla, cloves, and cinnamon.
- some types of nuts.
Does eczema affect the epithelial tissue?
Eczema affects the epithelial tissue of the skin, including the stratified squamous tissues, and causes inflammation of skin tissue in angry rashes and itchy welts.
Does eczema affect the nervous tissue?
These new findings confirm a direct role for the nervous system, which is responsible for the itchiness and was already implicated in the inflammation. “We, as a profession, have this thinking that eczema is an immune condition, and we forget that the immune system works with nerves,” Yosipovitch explained.
How does eczema cause inflammation?
People with eczema tend to have an over-reactive immune system that when triggered by a substance outside or inside the body, responds by producing inflammation. It is this inflammation that causes the red, itchy and painful skin symptoms common to most types of eczema.